Evidence of ventricular contamination of the optical signal in preterm neonates with post hemorrhagic ventricle dilation

J. Kishimoto; M. Diop; P. McLachlan; Sandrine de Ribaupierre; D.S.C. Lee; K. St. Lawrence

doi:10.1117/12.2077232

12 March 2015 Evidence of ventricular contamination of the optical signal in preterm neonates with post hemorrhagic ventricle dilation

J. Kishimoto, M. Diop, P. McLachlan, Sandrine de Ribaupierre, D.S.C. Lee, K. St. Lawrence

Author Affiliations +

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 931908 (2015) https://doi.org/10.1117/12.2077232
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Dilation of the cerebral ventricles is a common condition in preterm neonates with intraventricular hemorrhage (IVH). This post hemorrhagic ventricle dilation (PHVD) can lead to lifelong neurological impairment through ischemic injury due to increased intracranial pressure (ICP). Interventions, such as ventricular tapping to remove cerebrospinal fluid (CSF), are used to prevent injury, but determining the optimal time for treatment is difficult as clinical signs of increased ICP lack sensitivity. There is a growing interest in using near-infrared spectroscopy (NIRS) because of its ability to monitor cerebral oxygen saturation (S_tO₂) at the bedside. However, the accuracy of NIRS may be affected by signal contamination from enlarged ventricles, especially if there are blood breakdown products (bbp) in CSF following IVH. To investigate this, serial NIR spectra from the head and from CSF samples were acquired over a month from seven IVH patients undergoing treatment for PHVD. Over time, the visual appearance of the CSF samples progressed from dark brown (“tea color”) to clear yellow, reflecting the reduction in bbp concentration as confirmed by the stronger absorption around 760 nm at the earlier time points. All CSF samples contained strong absorption at 960 nm due to water. More importantly the same trend in these absorption features was observed in the in vivo spectra, and Monte Carlo simulations confirmed the potential for signal contamination from enlarged ventricles. These findings highlight the challenges of accurately measuring S_tO₂ in this patient population and the necessity of using a hyperspectral NIRS system to resolve the additional chromophores.

Citation Download Citation

J. Kishimoto, M. Diop, P. McLachlan, Sandrine de Ribaupierre, D.S.C. Lee, and K. St. Lawrence "Evidence of ventricular contamination of the optical signal in preterm neonates with post hemorrhagic ventricle dilation", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 931908 (12 March 2015); https://doi.org/10.1117/12.2077232

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available