A study on the quantitative evaluation of skin barrier function

Tomomi Maruyama M.D.; Yasuhiro Kabetani; Michiko Kido; Kenji Yamada; Hirotoshi Oikaze; Yohei Takechi; Tomotaka Furuta; Shoichi Ishii; Haruna Katayama; Hieyong Jeong; Yuko Ohno

doi:10.1117/12.2079655

4 March 2015 A study on the quantitative evaluation of skin barrier function

Tomomi Maruyama M.D., Yasuhiro Kabetani, Michiko Kido, Kenji Yamada, Hirotoshi Oikaze, Yohei Takechi, Tomotaka Furuta, Shoichi Ishii, Haruna Katayama, Hieyong Jeong, Yuko Ohno

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Proceedings Volume 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII; 93131F (2015) https://doi.org/10.1117/12.2079655
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We propose a quantitative evaluation method of skin barrier function using Optical Coherence Microscopy system (OCM system) with coherency of near-infrared light. There are a lot of skin problems such as itching, irritation and so on. It has been recognized skin problems are caused by impairment of skin barrier function, which prevents damage from various external stimuli and loss of water. To evaluate skin barrier function, it is a common strategy that they observe skin surface and ask patients about their skin condition. The methods are subjective judgements and they are influenced by difference of experience of persons. Furthermore, microscopy has been used to observe inner structure of the skin in detail, and in vitro measurements like microscopy requires tissue sampling. On the other hand, it is necessary to assess objectively skin barrier function by quantitative evaluation method. In addition, non-invasive and nondestructive measuring method and examination changes over time are needed. Therefore, in vivo measurements are crucial for evaluating skin barrier function. In this study, we evaluate changes of stratum corneum structure which is important for evaluating skin barrier function by comparing water-penetrated skin with normal skin using a system with coherency of near-infrared light. Proposed method can obtain in vivo 3D images of inner structure of body tissue, which is non-invasive and non-destructive measuring method. We formulate changes of skin ultrastructure after water penetration. Finally, we evaluate the limit of performance of the OCM system in this work in order to discuss how to improve the OCM system.

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Tomomi Maruyama M.D., Yasuhiro Kabetani, Michiko Kido, Kenji Yamada, Hirotoshi Oikaze, Yohei Takechi, Tomotaka Furuta, Shoichi Ishii, Haruna Katayama, Hieyong Jeong, and Yuko Ohno "A study on the quantitative evaluation of skin barrier function", Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 93131F (4 March 2015); https://doi.org/10.1117/12.2079655

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KEYWORDS

Skin

In vivo imaging

Microscopy

Nondestructive evaluation

Optical coherence microscopy

Tissues

Optical coherence tomography

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