Detection of protein kinases P38 based on reflectance spectroscopy with n-type porous silicon microcavities for diagnosing hydatidosis hydatid disease

Xiaoyi Lv; Guodong Lv; Zhenhong Jia; Jiajia Wang; Jiaqing Mo

doi:10.1117/12.2071332

20 November 2014 Detection of protein kinases P38 based on reflectance spectroscopy with n-type porous silicon microcavities for diagnosing hydatidosis hydatid disease

Xiaoyi Lv, Guodong Lv, Zhenhong Jia, Jiajia Wang, Jiaqing Mo

Author Affiliations +

Proceedings Volume 9268, Optics in Health Care and Biomedical Optics VI; 92681Q (2014) https://doi.org/10.1117/12.2071332
Event: SPIE/COS Photonics Asia, 2014, Beijing, China

Abstract

Detection of protein kinases P38 of Echinococcus granulosus and its homologous antibody have great value for early diagnosis and treatment of hydatidosis hydatid disease. In this experiment, n-type mesoporous silicon microcavities have been successfully fabricated without KOH etching or oxidants treatment that reported in other literature. We observed the changes of the reflectivity spectrum before and after the antigen-antibody reaction by n-type mesoporous silicon microcavities. The binding of protein kinases P38 and its homologous antibody causes red shifts in the reflection spectrum of the sensor, and the red shift was proportional to the protein kinases P38 concentration with linear relationship.

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Xiaoyi Lv, Guodong Lv, Zhenhong Jia, Jiajia Wang, and Jiaqing Mo "Detection of protein kinases P38 based on reflectance spectroscopy with n-type porous silicon microcavities for diagnosing hydatidosis hydatid disease", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92681Q (20 November 2014); https://doi.org/10.1117/12.2071332

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