Precise 13CO2/12CO2 isotopic ratio measurements for breath diagnosis with a 2 um diode laser

Mingguo Sun; Hongliang Ma; Zhensong Cao; Kun Liu; Guishi Wang; Lei Wang; Qiang Liu; Xiaoming Gao

doi:10.1117/12.2071221

20 November 2014 Precise ¹³CO₂/¹²CO₂ isotopic ratio measurements for breath diagnosis with a 2-μm diode laser

Mingguo Sun, Hongliang Ma, Zhensong Cao, Kun Liu, Guishi Wang, Lei Wang, Qiang Liu, Xiaoming Gao

Proceedings Volume 9268, Optics in Health Care and Biomedical Optics VI; 92681O (2014) https://doi.org/10.1117/12.2071221
Event: SPIE/COS Photonics Asia, 2014, Beijing, China

Abstract

A laser spectrometer based on a distributed-feedback semiconductor diode laser at 2 μm is developed to measure the changes of ¹³CO₂/¹²CO₂ isotope ratio in exhaled breath sample with the CO₂ concentration of ~4%. It is characterized by a simplified optical layout, in which a single detector and associated electronics are used to probe CO₂ spectrum. The cell has 10 cm long base length with 26.4 m optical path length in total and 330 cm³ volume. The cell pressure and temperature are controlled at 50 Torr and 28℃, respectively. The best ¹³δ precision of 0.06‰ was achieved by using wavelet denoising and Kalman filter.

Citation Download Citation

Mingguo Sun, Hongliang Ma, Zhensong Cao, Kun Liu, Guishi Wang, Lei Wang, Qiang Liu, and Xiaoming Gao "Precise ¹³CO₂/¹²CO₂ isotopic ratio measurements for breath diagnosis with a 2-μm diode laser", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92681O (20 November 2014); https://doi.org/10.1117/12.2071221

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