Microstructure analysis of the secondary pulmonary lobules by 3D synchrotron radiation CT

Y. Fukuoka; Y. Kawata; N. Niki; K. Umetani; Y. Nakano; H. Ohmatsu; N. Moriyama; H. Itoh

doi:10.1117/12.2043454

18 March 2014 Microstructure analysis of the secondary pulmonary lobules by 3D synchrotron radiation CT

Y. Fukuoka, Y. Kawata, N. Niki, K. Umetani, Y. Nakano, H. Ohmatsu, N. Moriyama, H. Itoh

Proceedings Volume 9035, Medical Imaging 2014: Computer-Aided Diagnosis; 90352F (2014) https://doi.org/10.1117/12.2043454
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Recognition of abnormalities related to the lobular anatomy has become increasingly important in the diagnosis and differential diagnosis of lung abnormalities at clinical routines of CT examinations. This paper aims a 3-D microstructural analysis of the pulmonary acinus with isotropic spatial resolution in the range of several micrometers by using micro CT. Previously, we demonstrated the ability of synchrotron radiation micro CT (SRμCT) using offset scan mode in microstructural analysis of the whole part of the secondary pulmonary lobule. In this paper, we present a semiautomatic method to segment the acinar and subacinar airspaces from the secondary pulmonary lobule and to track small vessels running inside alveolar walls in human acinus imaged by the SRμCT. The method beains with and segmentation of the tissues such as pleural surface, interlobular septa, alveola wall, or vessel using a threshold technique and 3-D connected component analysis. 3-D air space are then conustructed separated by tissues and represented branching patterns of airways and airspaces distal to the terminal bronchiole. A graph-partitioning approach isolated acini whose stems are interactively defined as the terminal bronchiole in the secondary pulmonary lobule. Finally, we performed vessel tracking using a non-linear sate space which captures both smoothness of the trajectories and intensity coherence along vessel orientations. Results demonstrate that the proposed method can extract several acinar airspaces from the 3-D SRμCT image of secondary pulmonary lobule and that the extracted acinar airspace enable an accurate quantitative description of the anatomy of the human acinus for interpretation of the basic unit of pulmonary structure and function.

Citation Download Citation

Y. Fukuoka, Y. Kawata, N. Niki, K. Umetani, Y. Nakano, H. Ohmatsu, N. Moriyama, and H. Itoh "Microstructure analysis of the secondary pulmonary lobules by 3D synchrotron radiation CT", Proc. SPIE 9035, Medical Imaging 2014: Computer-Aided Diagnosis, 90352F (18 March 2014); https://doi.org/10.1117/12.2043454

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Image segmentation

Lung

Synchrotron radiation

3D image processing

Arteries

Veins

Computed tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years