The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles

Olga V. Zlobina; Svetlana S. Pakhomy; Alla B. Bucharskaya; Irina O. Bugaeva; Galina N. Maslyakova; Nikolai G. Khlebtsov; Boris N. Khlebtsov; Vladimir A. Bogatyrev

doi:10.1117/12.2048990

30 January 2014 The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles

Olga V. Zlobina, Svetlana S. Pakhomy, Alla B. Bucharskaya, Irina O. Bugaeva, Galina N. Maslyakova, Nikolai G. Khlebtsov, Boris N. Khlebtsov, Vladimir A. Bogatyrev

Author Affiliations +

Proceedings Volume 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV; 90310P (2014) https://doi.org/10.1117/12.2048990
Event: Saratov Fall Meeting 2013, 2013, Saratov, Russian Federation

Abstract

The oral administration of gold nanoparticles at dose 190 mg /kg animal body weight during 8 days leads to changes in the cellular composition of the mesenteric lymph nodes, the severity and reversibility of the reaction was determined by the size of gold nanoparticles. The cellular composition of the lymph nodes after the introduction of gold nanoparticle size of 1-3 nm for 8 days corresponded the control values, indicating the absence of immunotoxicity. Duration of recovery of cellular composition of the lymph nodes after administration of gold nanoparticles with size 15 nm and 50 nm does not exceed 21 days. It can be concluded that 15 nm and 50 nm nanoparticles have no immunotoxic action at oral administration.

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Olga V. Zlobina, Svetlana S. Pakhomy, Alla B. Bucharskaya, Irina O. Bugaeva, Galina N. Maslyakova, Nikolai G. Khlebtsov, Boris N. Khlebtsov, and Vladimir A. Bogatyrev "The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310P (30 January 2014); https://doi.org/10.1117/12.2048990

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