Evaluation of lipid peroxidation activity at intravenous administration of gold nanorods in rats with simulated diabetes and transplanted liver cancer

Alla B. Bucharskaya; Natalia I. Dikht; Galina A. Afanasyeva; Georgy S. Terentyuk; Galina N. Maslyakova; Nadezhda V. Zaraeva; Nikolai G. Khlebtsov; Boris N. Khlebtsov

doi:10.1117/12.2048988

30 January 2014 Evaluation of lipid peroxidation activity at intravenous administration of gold nanorods in rats with simulated diabetes and transplanted liver cancer

Alla B. Bucharskaya, Natalia I. Dikht, Galina A. Afanasyeva, Georgy S. Terentyuk, Galina N. Maslyakova, Nadezhda V. Zaraeva, Nikolai G. Khlebtsov, Boris N. Khlebtsov

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Proceedings Volume 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV; 90310O (2014) https://doi.org/10.1117/12.2048988
Event: Saratov Fall Meeting 2013, 2013, Saratov, Russian Federation

Abstract

In the experiment the white outbred rats with transplanted liver cancer (cholangiocarcinoma line PC-1) and simulated alloxan diabetes were treated by single intravenous injection of gold nanorods. State of lipid peroxidation was evaluated by the following parameters: the malondialdehyde, lipid hydroperoxide, the average weght molecules in the serum of animals by conventional spectrophotometric methods study using a spectrofluorometer RF-5301 PC (Shimadzu, Japan). In both experimental groups of animals the significant increasing of levels of lipid peroxidation products was noted compared with control group. After intravenous administration of nanoparticles in the group of animals with alloxan diabetes the activation of a free radical oxidation was not observed, in group with transplanted liver cancer the increasing of levels of lipid hydroperoxide, malondialdehyde was established.

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Alla B. Bucharskaya, Natalia I. Dikht, Galina A. Afanasyeva, Georgy S. Terentyuk, Galina N. Maslyakova, Nadezhda V. Zaraeva, Nikolai G. Khlebtsov, and Boris N. Khlebtsov "Evaluation of lipid peroxidation activity at intravenous administration of gold nanorods in rats with simulated diabetes and transplanted liver cancer", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310O (30 January 2014); https://doi.org/10.1117/12.2048988

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