Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice

Akinori Taketani; Mika Ishigaki; Bibin Bintan Andriana; Hidetoshi Sato

doi:10.1117/12.2038939

28 February 2014 Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice

Akinori Taketani, Mika Ishigaki, Bibin Bintan Andriana, Hidetoshi Sato

Author Affiliations +

Proceedings Volume 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics; 89510O (2014) https://doi.org/10.1117/12.2038939
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The aim of the present study is to evaluate the capability of a miniaturized Raman endoscope (mRE) system to monitor the advancement of colorectal tumors in live model mice. The endoscope is narrow enough to observe the inside of the mouse colon under anesthesia. The mRE system allows to observe the tissues and to apply a miniaturized Raman probe for the measurement at any targeted point within the colon. Raman spectroscopy allows obtaining information about molecular composition without damaging the tissue (i.e., noninvasively). Continuous monitoring of the same tumor is carried out to study molecular alterations along with its advancement. The Raman spectra measured before and after the anticancer drug (5-FU) treatment indicated spectral changes in the tumor tissue. It suggests that the tumor is not cured but supposedly transformed to another tumor type after the treatment.

Citation Download Citation

Akinori Taketani, Mika Ishigaki, Bibin Bintan Andriana, and Hidetoshi Sato "Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 89510O (28 February 2014); https://doi.org/10.1117/12.2038939

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