Fluorescent nanodiamonds for ultrasensitive detection

Joseph Kimball; Dmytro Shumilov; Badri Maliwa; T. W. Zerda; Bibhu Rout; Rafal Fudala; Sangram Raut; Ignacy Gryczynski; Eric Simanek; Julian Borejdo; Ryan Rich; Irina Akopova; Zygmunt Gryczynski

doi:10.1117/12.2045376

4 March 2014 Fluorescent nanodiamonds for ultrasensitive detection

Joseph Kimball, Dmytro Shumilov, Badri Maliwa, T. W. Zerda, Bibhu Rout, Rafal Fudala, Sangram Raut, Ignacy Gryczynski, Eric Simanek, Julian Borejdo, Ryan Rich, Irina Akopova, Zygmunt Gryczynski

Author Affiliations +

Proceedings Volume 8950, Single Molecule Spectroscopy and Superresolution Imaging VII; 89501H (2014) https://doi.org/10.1117/12.2045376
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Fluorescent nanodiamonds (NDs) are new and emerging nanomaterials that have potential to be used as fluorescence imaging agents and also as a highly versatile platform for the controlled functionalization and delivery of a wide spectrum of therapeutic agents. We will utilize two experimental methods, TIRF, a relatively simple method based on total internal reflection fluorescence and SPRF, fluorescence enhanced by resonance coupling with surface plasmons. We estimate that the SPRF method will be 100 times sensitive than currently available similar detectors based on detectors. The ultimate goal of this research is to develop microarray platforms that could be used for sensitive, fast and inexpensive gene sequencing and protein detection.

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Joseph Kimball, Dmytro Shumilov, Badri Maliwa, T. W. Zerda, Bibhu Rout, Rafal Fudala, Sangram Raut, Ignacy Gryczynski, Eric Simanek, Julian Borejdo, Ryan Rich, Irina Akopova, and Zygmunt Gryczynski "Fluorescent nanodiamonds for ultrasensitive detection", Proc. SPIE 8950, Single Molecule Spectroscopy and Superresolution Imaging VII, 89501H (4 March 2014); https://doi.org/10.1117/12.2045376

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