Application of ball-lens hollow fiber Raman probe for studying anorectal prolapse

Bibin Bintang Andriana; Akinori Taketani; C. Linda R. Soeratman; Mika Ishigaki; Yasuhiro Maeda; Masanori Sawa; Hidetoshi Sato

doi:10.1117/12.2037884

20 February 2014 Application of ball-lens hollow fiber Raman probe for studying anorectal prolapse

Bibin Bintang Andriana, Akinori Taketani, C. Linda R. Soeratman, Mika Ishigaki, Yasuhiro Maeda, Masanori Sawa, Hidetoshi Sato

Author Affiliations +

Proceedings Volume 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV; 893816 (2014) https://doi.org/10.1117/12.2037884
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Our Raman probe that is called as ball-lens hollow fiber Raman probe (BHRP) had been proved possessing capability to detect the biochemical alteration within biological tissue. Whether BHRP has high capability and sensitivity in diagnosing the biochemical changing of tissue or not, mouse's normal rectal and anorectal prolapse (AP) were decided to be used as a model for this non invasive method. This AP is azoxymethane and DSS-induced mouse’s anorectal prolapse. Main outcome of BHRP will be potential for non-invasive method in tumor diagnosing. BHRP spectra obtained were a high quality and allowed analysis of their differences between normal rectal (control group) and AP. After spectral acquisition and comparison with corresponding images of hematoxylin/eosinstained section observation used to make the histopathologic diagnosing, BHRP detected some differences within the region of moiety of DNA, protein (i.e. collagen) and lipid, then following with the alteration of symmetric P=O stretching vibration compared with the normal rectal tissue. BHRP discriminate normal tissue and AP in the real-time.

Citation Download Citation

Bibin Bintang Andriana, Akinori Taketani, C. Linda R. Soeratman, Mika Ishigaki, Yasuhiro Maeda, Masanori Sawa, and Hidetoshi Sato "Application of ball-lens hollow fiber Raman probe for studying anorectal prolapse", Proc. SPIE 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV, 893816 (20 February 2014); https://doi.org/10.1117/12.2037884

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Raman spectroscopy

Tissues

Tumors

Decision support systems

Bragg cells

Statistical modeling

Collagen

Show All Keywords

Keywords/Phrases

Search In:

Publication Years