Scanning Fiber Endoscope with multiple fluorescence-reflectance imaging channels for guiding biopsy

Chenying Yang; Vivian W. Hou; Leonard Y. Nelson; Richard S. Johnston; C. David Melville; Eric J. Seibel

doi:10.1117/12.2038544

4 March 2014 Scanning Fiber Endoscope with multiple fluorescence-reflectance imaging channels for guiding biopsy

Chenying Yang, Vivian W. Hou, Leonard Y. Nelson, Richard S. Johnston, C. David Melville, Eric J. Seibel

Proceedings Volume 8936, Design and Quality for Biomedical Technologies VII; 89360R (2014) https://doi.org/10.1117/12.2038544
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Fluorescence-labeled molecular probes can be used during endoscopy for early cancer detection. As many tumors express multiple cell surface markers and these molecular signatures are heterogeneous across patients, simultaneous imaging of numerous different molecular targets is important for increasing the sensitivity of early cancer diagnosis and personalized treatment. For this purpose, a wide-field, multi-spectral fluorescence-reflectance scanning fiber endoscope (SFE) has been developed. Using a set of calibrated fluorescent test targets at in vivo dye concentration, algorithms and methodologies were developed and demonstrated. Preliminary results showed the promise of fluorescence molecular imaging in clinical applications using the multi-spectral SFE.

Citation Download Citation

Chenying Yang, Vivian W. Hou, Leonard Y. Nelson, Richard S. Johnston, C. David Melville, and Eric J. Seibel "Scanning Fiber Endoscope with multiple fluorescence-reflectance imaging channels for guiding biopsy", Proc. SPIE 8936, Design and Quality for Biomedical Technologies VII, 89360R (4 March 2014); https://doi.org/10.1117/12.2038544

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