Optical-thermal light-tissue interactions during photoacoustic imaging

Taylor Gould; Quanzeng Wang; T. Joshua Pfefer

doi:10.1117/12.2044379

4 March 2014 Optical-thermal light-tissue interactions during photoacoustic imaging

Taylor Gould, Quanzeng Wang, T. Joshua Pfefer

Proceedings Volume 8936, Design and Quality for Biomedical Technologies VII; 893603 (2014) https://doi.org/10.1117/12.2044379
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Photoacoustic imaging (PAI) has grown rapidly as a biomedical imaging technique in recent years, with key applications in cancer diagnosis and oximetry. In spite of these advances, the literature provides little insight into thermal tissue interactions involved in PAI. To elucidate these basic phenomena, we have developed, validated, and implemented a three-dimensional numerical model of tissue photothermal (PT) response to repetitive laser pulses. The model calculates energy deposition, fluence distributions, transient temperature and damage profiles in breast tissue with blood vessels and generalized perfusion. A parametric evaluation of these outputs vs. vessel diameter and depth, optical beam diameter, wavelength, and irradiance, was performed. For a constant radiant exposure level, increasing beam diameter led to a significant increase in subsurface heat generation rate. Increasing vessel diameter resulted in two competing effects – reduced mean energy deposition in the vessel due to light attenuation and greater thermal superpositioning due to reduced thermal relaxation. Maximum temperatures occurred either at the surface or in subsurface regions of the dermis, depending on vessel geometry and position. Results are discussed in terms of established exposure limits and levels used in prior studies. While additional experimental and numerical study is needed, numerical modeling represents a powerful tool for elucidating the effect of PA imaging devices on biological tissue.

Citation Download Citation

Taylor Gould, Quanzeng Wang, and T. Joshua Pfefer "Optical-thermal light-tissue interactions during photoacoustic imaging", Proc. SPIE 8936, Design and Quality for Biomedical Technologies VII, 893603 (4 March 2014); https://doi.org/10.1117/12.2044379

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KEYWORDS

Tissues

Tissue optics

Blood vessels

Laser tissue interaction

Pulsed laser operation

3D modeling

Skin

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