Analysis and digital 3D modeling of long-range fourier-domain optical coherence tomography images of the pediatric subglottis

Erica Su; Giriraj K. Sharma M.D.; Jason Chen; Tony D. Nguyen; Alex Wang; Ashley Hamamoto; Gurpreet S. Ahuja; Zhongping Chen; Brian J-F. Wong M.D.

doi:10.1117/12.2052793

31 March 2014 Analysis and digital 3D modeling of long-range fourier-domain optical coherence tomography images of the pediatric subglottis

Erica Su, Giriraj K. Sharma M.D., Jason Chen, Tony D. Nguyen, Alex Wang, Ashley Hamamoto, Gurpreet S. Ahuja, Zhongping Chen, Brian J-F. Wong M.D.

Author Affiliations +

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89262J (2014) https://doi.org/10.1117/12.2052793
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

In neonatal and pediatric patients who require long-term endotracheal intubation, the subglottic mucosa is most susceptible to injury from the endotracheal tube. At present, there is no diagnostic modality to identify early signs of subglottic mucosal pathology. Fourier-domain optical coherence tomography (FD-OCT) is a minimally-invasive imaging modality which acquires high-resolution, 3D cross-sectional images of biological tissue. FD-OCT of the neonatal and pediatric airways was conducted to evaluate subglottic microanatomy and histopathologic changes associated with prolonged intubation. FD-OCT of the larynx, subglottis and proximal trachea was conducted in pediatric and neonatal patients. OCT image sets were analyzed by anatomic categorization (airway level), tissue segmentation and mucosa micrometry in MATLAB. Subsequently, OCT data sets were rendered into digital 3D airway models in Mimics software. We report original methods for subglottic OCT image processing and analysis.

Citation Download Citation

Erica Su, Giriraj K. Sharma M.D., Jason Chen, Tony D. Nguyen, Alex Wang, Ashley Hamamoto, Gurpreet S. Ahuja, Zhongping Chen, and Brian J-F. Wong M.D. "Analysis and digital 3D modeling of long-range fourier-domain optical coherence tomography images of the pediatric subglottis", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262J (31 March 2014); https://doi.org/10.1117/12.2052793

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available