High resolution in-vivo imaging of skin with full field optical coherence tomography

E. Dalimier; Alexis Bruhat; K. Grieve; F. Harms; F. Martins; C. Boccara

doi:10.1117/12.2037747

4 March 2014 High resolution in-vivo imaging of skin with full field optical coherence tomography

E. Dalimier, Alexis Bruhat, K. Grieve, F. Harms, F. Martins, C. Boccara

Proceedings Volume 8926, Photonic Therapeutics and Diagnostics X; 89260P (2014) https://doi.org/10.1117/12.2037747
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Full-field OCT (FFOCT) has the ability to provide en-face images with a very good axial sectioning as well as a very high transverse resolution (about 1 microns in all directions). Therefore it offers the possibility to visualize biological tissues with very high resolution both on the axial native view, and on vertical reconstructed sections. Here we investigated the potential dermatological applications of in-vivo skin imaging with FFOCT. A commercial FFOCT device was adapted for the in-vivo acquisition of stacks of images on the arm, hand and finger. Several subjects of different benign and pathological skin conditions were tested. The images allowed measurement of the stratum corneum and epidermis thicknesses, measurement of the stratum corneum refractive index, size measurement and count of the keratinocytes, visualization of the dermal-epidermal junction, and visualization of the melanin granules and of the melanocytes. Skins with different pigmentations could be discriminated and skin pathologies such as eczema could be identified. The very high resolution offered by FFOCT both on axial native images and vertical reconstructed sections allows for the visualization and measurement of a set of parameters useful for cosmetology and dermatology. In particular, FFOCT is a potential tool for the understanding and monitoring of skin hydration and pigmentation, as well as skin inflammation.

Citation Download Citation

E. Dalimier, Alexis Bruhat, K. Grieve, F. Harms, F. Martins, and C. Boccara "High resolution in-vivo imaging of skin with full field optical coherence tomography", Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89260P (4 March 2014); https://doi.org/10.1117/12.2037747

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