Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells

Chiara Paviolo; John W. Haycock; Paul R. Stoddart; Sally L. McArthur

doi:10.1117/12.2033575

7 December 2013 Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells

Chiara Paviolo, John W. Haycock, Paul R. Stoddart, Sally L. McArthur

Author Affiliations +

Proceedings Volume 8923, Micro/Nano Materials, Devices, and Systems; 89231A (2013) https://doi.org/10.1117/12.2033575
Event: SPIE Micro+Nano Materials, Devices, and Applications, 2013, Melbourne, Victoria, Australia

Abstract

Gold nanorods with citrate termination, poly(4 - styrenesulfonic acid) coating and silica coating were taken up by NG108 - K15 neuronal cells. This process proved to generate reactive oxygen species (ROS) and activate the nuclear factor κ -B (NF - κB). However, subsequent exposure to laser light at the plasmon resonance wavelength showed no long term cell damage or ROS / NF- κB activation. Interestingly, monitoring of intracellular Ca²⁺ signaling showed evidence of photo - generated transients without alteration of other normal cell functions. These results suggest new opportunities for peripheral nerve regeneration treatments and for infrared neural stimulation.

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Chiara Paviolo, John W. Haycock, Paul R. Stoddart, and Sally L. McArthur "Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells", Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 89231A (7 December 2013); https://doi.org/10.1117/12.2033575

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