Water-soluble benzylidene cyclopentanone photosensitizers for two-photon excited photodynamic therapy

Yanyan Fang; Hongyou Zhao; Qianli Zou; Yuxia Zhao; Ying Gu; Feipeng Wu

doi:10.1117/12.2033302

7 December 2013 Water-soluble benzylidene cyclopentanone photosensitizers for two-photon excited photodynamic therapy

Yanyan Fang, Hongyou Zhao, Qianli Zou, Yuxia Zhao, Ying Gu, Feipeng Wu

Proceedings Volume 8923, Micro/Nano Materials, Devices, and Systems; 892319 (2013) https://doi.org/10.1117/12.2033302
Event: SPIE Micro+Nano Materials, Devices, and Applications, 2013, Melbourne, Victoria, Australia

Abstract

A series of benzylidene cyclopentanone photosensitizers modified by polyethylene glycol, carboxylate anionic or pyridyl cationic groups with gradient lipid-water partition coefficients were reported. Detailed characterization and systematic studies of these photosensitizers, including their linear and nonlinear photophysical properties, in vitro photodynamic therapy (PDT) and two-photon excited PDT (2PE–PDT) activities were conducted and compared with a clinical drug PSD-007 (a mixture of porphyrins). Three of them exhibited appropriate lipid-water partition coefficients, high reactive oxygen yields, large two-photon absorption cross-section and low dark toxicity under therapy dosage, could be absorbed efficiently by liver hepatocellular HepG2 cells and presented strong PDT and 2PE-PDT activity by in vitro cell experiments. Furthermore, in vivo tumor experiments were carried out on BALB/c mouse models using B3 as the photosensitizer. The results showed that the tumor growth could be effectively suppressed by B3 under 2PE-PDT. This work demonstrated the feasibility of using a simple molecular structure to construct high efficient photosensitizers for 2PE-PDT.

Citation Download Citation

Yanyan Fang, Hongyou Zhao, Qianli Zou, Yuxia Zhao, Ying Gu, and Feipeng Wu "Water-soluble benzylidene cyclopentanone photosensitizers for two-photon excited photodynamic therapy", Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 892319 (7 December 2013); https://doi.org/10.1117/12.2033302

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