The phase detection method in continuous monitoring of pH during the process of cell culture

Zemin Liu; Wei Tao; Hui Zhao; Jinke Cheng

doi:10.1117/12.2014577

31 January 2013 The phase detection method in continuous monitoring of pH during the process of cell culture

Zemin Liu, Wei Tao, Hui Zhao, Jinke Cheng

Proceedings Volume 8759, Eighth International Symposium on Precision Engineering Measurement and Instrumentation; 875924 (2013) https://doi.org/10.1117/12.2014577
Event: International Symposium on Precision Engineering Measurement and Instrumentation 2012, 2012, Chengdu, China

Abstract

The pH value has been one of the keen parameters in the cell culture. And the optical measurement method especially the optical method using optical fiber has been widely used due to its small volume and high accuracy. In this work we design a phase detection system to detect the phase difference between the signal and reference signal in the Dual Lifetime Referencing Method. The modulation frequency of the DLR method ranges from 10 kHz to 60 kHz and the system we designed can detect phase difference from the frequency of 1 kHz to 100 kHz. The error can be as small as 0.2%.

Citation Download Citation

Zemin Liu, Wei Tao, Hui Zhao, and Jinke Cheng "The phase detection method in continuous monitoring of pH during the process of cell culture", Proc. SPIE 8759, Eighth International Symposium on Precision Engineering Measurement and Instrumentation, 875924 (31 January 2013); https://doi.org/10.1117/12.2014577

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