Circulating exosomes as new biomarkers for brain disease and injury

Michael W. Graner; Laura M. Epple; Nathaniel L. Dusto; Alex M. Lencioni; Meheret Nega; Matthew Herring; Ben Winston; Helen Madsen; Lynne T. Bemis; Thomas J. Anchordoquy

doi:10.1117/12.2027435

29 May 2013 Circulating exosomes as new biomarkers for brain disease and injury

Michael W. Graner, Laura M. Epple, Nathaniel L. Dusto, Alex M. Lencioni, Meheret Nega, Matthew Herring, Ben Winston, Helen Madsen, Lynne T. Bemis, Thomas J. Anchordoquy

Author Affiliations +

Proceedings Volume 8723, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III; 87230R (2013) https://doi.org/10.1117/12.2027435
Event: SPIE Defense, Security, and Sensing, 2013, Baltimore, Maryland, United States

Abstract

Brain diseases such as cancers, neurodegenerative disorders, or trauma are frequently diagnosed with imaging modalities and sometimes with intracranial biopsies. Treatment response is similarly monitored, along with clinical indications. While these technologies provide important windows into the disease state, they fail to provide us a detailed molecular portrait of the disease and of the changes taking place during therapy. Exosomes are virus-sized nanovesicles derived from the endosomal system and are released extracellularly from essentially all cell types. Exosomes contain intracellular entities (proteins, nucleic acids, metabolites), membrane proteins and lipids, and even extracellular proteins bound to them. Exosomes may be considered as mini-surrogates of their cells of origin, with some content common to all cells/exosomes, but some of the content would be cell-specific. These vesicles are found in all biofluids in humans, and are thus accessible to “liquid biopsy” with harvest of vesicles from such fluids. Current challenges are to identify disease-related markers or panels of markers to distinguish the disease state. Here we will show examples of brain tumor markers found in/on exosomes from cell culture and patient sera, and we will suggest that aspects of the biology of disease may have a relevant place in the search for biomarkers.

Citation Download Citation

Michael W. Graner, Laura M. Epple, Nathaniel L. Dusto, Alex M. Lencioni, Meheret Nega, Matthew Herring, Ben Winston, Helen Madsen, Lynne T. Bemis, and Thomas J. Anchordoquy "Circulating exosomes as new biomarkers for brain disease and injury", Proc. SPIE 8723, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, 87230R (29 May 2013); https://doi.org/10.1117/12.2027435

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available