Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea

Hrebesh M. Subhash; Ruikang K. Wang; Fangyi Chen; Alfred L. Nuttall

doi:10.1117/12.2002540

20 March 2013 Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea

Hrebesh M. Subhash, Ruikang K. Wang, Fangyi Chen, Alfred L. Nuttall

Author Affiliations +

Proceedings Volume 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII; 85713G (2013) https://doi.org/10.1117/12.2002540
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Most of the optical coherence tomographic (OCT) systems for high resolution imaging of biological specimens are based on refractive type microscope objectives, which are optimized for specific wave length of the optical source. In this study, we present the feasibility of using commercially available reflective type objective for high sensitive and high resolution structural and functional imaging of cochlear microstructures of an excised guinea pig through intact temporal bone. Unlike conventional refractive type microscopic objective, reflective objective are free from chromatic aberrations due to their all-reflecting nature and can support a broadband of spectrum with very high light collection efficiency.

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Hrebesh M. Subhash, Ruikang K. Wang, Fangyi Chen, and Alfred L. Nuttall "Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea", Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 85713G (20 March 2013); https://doi.org/10.1117/12.2002540

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