Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement

Shang Wang; Jiasong Li; Srilatha Vantipalli; Ravi Kiran Manapuram; Davis R. Ingram; Michael D. Twa; Alexander J. Lazar; Dina C. Lev; Raphael E. Pollock; Kirill V. Larin

doi:10.1117/12.2007156

20 March 2013 Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement

Shang Wang, Jiasong Li, Srilatha Vantipalli, Ravi Kiran Manapuram, Davis R. Ingram, Michael D. Twa, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, Kirill V. Larin

Author Affiliations +

Proceedings Volume 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII; 85712B (2013) https://doi.org/10.1117/12.2007156
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We combine a focused air-puff system with phase-sensitive optical coherence tomography (PhS-OCT) to measure the elasticity of soft tissues. Surface waves (SWs) on soft tissues are induced by a low-pressure, short-duration air stream from an air-puff system and measured using a high-sensitivity PhS-OCT imaging system. Young’s modulus of soft tissues can be quantified based on the group velocity of SWs. To precisely control the excitation pressure, the air-puff system was characterized with a high-resolution analog pressure transducer. We studied the feasibility of this method for the non-contact detection of soft-tissue tumors. Ex vivo human fat and myxoma were used for these pilot experiments. Results demonstrate that this optical non-contact technique can be used to differentiate soft-tissue tumors from normal tissues based on measurements of their elasticity.

Citation Download Citation

Shang Wang, Jiasong Li, Srilatha Vantipalli, Ravi Kiran Manapuram, Davis R. Ingram, Michael D. Twa, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, and Kirill V. Larin "Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement", Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 85712B (20 March 2013); https://doi.org/10.1117/12.2007156

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