Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography

D. Alonso-Caneiro; M. Yamanari; S. Fukuda; S. Hoshi; S. Nagase; T. Oshika; Y. Yasuno; M. Collins

doi:10.1117/12.2002988

26 March 2013 Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography

D. Alonso-Caneiro, M. Yamanari, S. Fukuda, S. Hoshi, S. Nagase, T. Oshika, Y. Yasuno, M. Collins

Author Affiliations +

Proceedings Volume 8567, Ophthalmic Technologies XXIII; 85670F (2013) https://doi.org/10.1117/12.2002988
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Collagen crosslinking (CXL) has shown promising results in the prevention of the progression of keratoconus and corneal ectasia. However, techniques for in vivo and in situ assessment of the treatment are limited. In this study, ex vivo porcine eyes were treated with a chemical CXL agent (glutaraldehyde), during which polarization sensitive optical coherence tomography (PS-OCT) recordings were acquired simultaneously to assess the sensitivity of the technique to assess changes in the cornea. The results obtained in this study suggest that PSOCT may be a suitable technique to measure CXL changes in situ and to assess the local changes in the treated region of the cornea.

Citation Download Citation

D. Alonso-Caneiro, M. Yamanari, S. Fukuda, S. Hoshi, S. Nagase, T. Oshika, Y. Yasuno, and M. Collins "Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography", Proc. SPIE 8567, Ophthalmic Technologies XXIII, 85670F (26 March 2013); https://doi.org/10.1117/12.2002988

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