Bionanocomposites based on layered double hydroxides as drug delivery systems

Pilar Aranda; Ana C. S. Alcântara; Ligia N. M. Ribeiro; Margarita Darder; Eduardo Ruiz-Hitzky

doi:10.1117/12.2008317

24 October 2012 Bionanocomposites based on layered double hydroxides as drug delivery systems

Pilar Aranda, Ana C. S. Alcântara, Ligia N. M. Ribeiro, Margarita Darder, Eduardo Ruiz-Hitzky

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85486D (2012) https://doi.org/10.1117/12.2008317
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

The present work introduces new biohybrid materials involving layered double hydroxides (LDH) and biopolymers to produce bionanocomposites, able to act as effective drug delivery systems (DDS). Ibuprofen (IBU) and 5-aminosalicylic acid (5-ASA) have been chosen as model drugs, being intercalated in a Mg–Al LDH matrix. On the one side, the LDHIBU intercalation compound prepared by ion-exchange reaction was blended with the biopolymers zein, a highly hydrophobic protein, and alginate, a polysaccharide widely applied for encapsulating drugs. On the other side, the LDH- 5-ASA intercalation compound prepared by co-precipitation was assembled to the polysaccharides chitosan and pectin, which show mucoadhesive properties and resistance to acid pH values, respectively. Characterization of the intercalation compounds and the resulting bionanocomposites was carried out by means of different experimental techniques: X-ray diffraction, infrared spectroscopy, chemical and thermal analysis, as well as optical and scanning electron microscopies. Data on the swelling behavior and drug release under different pH conditions are also reported.

Citation Download Citation

Pilar Aranda, Ana C. S. Alcântara, Ligia N. M. Ribeiro, Margarita Darder, and Eduardo Ruiz-Hitzky "Bionanocomposites based on layered double hydroxides as drug delivery systems", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85486D (24 October 2012); https://doi.org/10.1117/12.2008317

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