Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy

Taeksu Lee; Doyeon Bang; Jin-Suck Suh; Yong-Min Huh; Seungjoo Haam

doi:10.1117/12.2001967

24 October 2012 Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy

Taeksu Lee, Doyeon Bang, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85482E (2012) https://doi.org/10.1117/12.2001967
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

The ultrasensitive and selective diagnosis along with efficient therapy in earliest stage of cancer has been enormously highlighted by a better means to treat the cancer. Herein, Gd (III) chelated polyaniline nanoparticles (GPNPs) was synthesized to be served as a highly T₁ enhanced contrast agents and Near-Infrared photothermal therapy probes. In addition, therapeutic antibody was conjugated on the surface of GPNPs for the targeted theragnosis. Fabricated GPNPs significantly reduced the T₁ of water protons with as well as represented photothermal ability. The physicochemical properties and biocompatibilities of GNPSs were fully characterized and GPNPs exhibited excellent tumor targeting ability. Consequently, GPNPs exhibited strong potential for efficient diagnosis of cancer in MR imaging and photothermal ablation of epithelial cancer cells.

Citation Download Citation

Taeksu Lee, Doyeon Bang, Jin-Suck Suh, Yong-Min Huh, and Seungjoo Haam "Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482E (24 October 2012); https://doi.org/10.1117/12.2001967

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