Novel algorithms in coherent diffraction imaging using x-ray free-electron lasers

Chunhong Yoon

doi:10.1117/12.953634

19 October 2012 Novel algorithms in coherent diffraction imaging using x-ray free-electron lasers

Chunhong Yoon

Proceedings Volume 8500, Image Reconstruction from Incomplete Data VII; 85000H (2012) https://doi.org/10.1117/12.953634
Event: SPIE Optical Engineering + Applications, 2012, San Diego, California, United States

Abstract

The emergence of X-ray Free-Electron Lasers has enabled coherent diffraction imaging of single nanoparticles by outrunning radiation damage with an intense ultrafast X-ray pulse. A 3D reconstruction from an ensemble of 2D diffraction patterns requires recovery of the orientations of individual diffraction patterns. This assumes that each diffraction pattern comes from a slice of a common diffraction volume. In the presence of particle heterogeneity, this assumption does not hold and the recovered structure is severely degraded. In this paper, I review couple of emerging algorithms useful for dealing with conformational changes in a heterogeneous sample. A simulated case study of a “particle in motion” is included to demonstrate the algorithms and also show that these novel algorithms work in the presence of missing Fourier regions caused by new detector geometries at XFEL facilities.

Citation Download Citation

Chunhong Yoon "Novel algorithms in coherent diffraction imaging using x-ray free-electron lasers", Proc. SPIE 8500, Image Reconstruction from Incomplete Data VII, 85000H (19 October 2012); https://doi.org/10.1117/12.953634

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available