Photothermal nanoblade for single cell surgery and cargo delivery

Pei-Yu Chiou; Ting-Hsiang Wu; Michael A Teitell M.D.

doi:10.1117/12.930754

10 October 2012 Photothermal nanoblade for single cell surgery and cargo delivery

Pei-Yu Chiou, Ting-Hsiang Wu, Michael A Teitell M.D.

Proceedings Volume 8460, Biosensing and Nanomedicine V; 84600Q (2012) https://doi.org/10.1117/12.930754
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

This work presents a novel photothermal nanoblade that utilizes metallic nanostructures to light energy from short laser pulses to generate highly localized and shaped explosive cavitation bubbles which enables rapid cut of a lightly contacting cell membrane of a mammalian cell. Photothermal nanoblade can generate micrometer-sized membrane access ports for delivering large size cargo with high efficiency and high cell viability. Biologic and inanimate cargo over 3-orders of magnitude in size including DNA, RNA, 200 nm polystyrene beads, to 2 μm bacteria have also been successfully delivered into multiple mammalian cell types.

Citation Download Citation

Pei-Yu Chiou, Ting-Hsiang Wu, and Michael A Teitell M.D. "Photothermal nanoblade for single cell surgery and cargo delivery", Proc. SPIE 8460, Biosensing and Nanomedicine V, 84600Q (10 October 2012); https://doi.org/10.1117/12.930754

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