Portable guided-mode resonance biosensor platform for point-of-care testing

Gun Yong Sung; Wan-Joong Kim; Hyunsung Ko; Bong Kyu Kim; Kyung-Hyun Kim; Chul Huh; Jongcheol Hong

doi:10.1117/12.929457

10 October 2012 Portable guided-mode resonance biosensor platform for point-of-care testing

Gun Yong Sung, Wan-Joong Kim, Hyunsung Ko, Bong Kyu Kim, Kyung-Hyun Kim, Chul Huh, Jongcheol Hong

Proceedings Volume 8460, Biosensing and Nanomedicine V; 84600F (2012) https://doi.org/10.1117/12.929457
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

It represents a viable solution for the realization of a portable biosensor platform that could screen/diagnose acute myocardial infarction by measuring cardiac marker concentrations such as cardiac troponin I (cTnI), creatine kinase MB (CK-MB), and myoglobin (MYO) for application to u-health monitoring system. The portable biosensor platform introduced in this presentation has a more compact structure and a much higher measuring resolution than a conventional spectrometer system. Portable guided-mode resonance (GMR) biosensor platform was composed of a biosensor chip stage, an optical pick-up module, and a data display panel. Disposable plastic GMR biosensor chips with nano-grating patterns were fabricated by injection–molding. Whole blood filtration and label-free immunoassay were performed on these single chips, automatically. Optical pick-up module was fabricated by using the miniaturized bulk optics and the interconnecting optical fibers and a tunable VCSEL (vertical cavity surface emitting laser). The reflectance spectrum from the GMR biosensor was measured by the optical pick-up module. Cardiac markers in human serum with concentrations less than 0.1ng/mL were analyzed using a GMR biosensor. Analysis time was 30min, which is short enough to meet clinical requirements. Our results show that the GMR biosensor will be very useful in developing lowcost portable biosensors that can screen for cardiac diseases.

Citation Download Citation

Gun Yong Sung, Wan-Joong Kim, Hyunsung Ko, Bong Kyu Kim, Kyung-Hyun Kim, Chul Huh, and Jongcheol Hong "Portable guided-mode resonance biosensor platform for point-of-care testing", Proc. SPIE 8460, Biosensing and Nanomedicine V, 84600F (10 October 2012); https://doi.org/10.1117/12.929457

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