Measurement of PLGA-NP interaction with a single smooth muscle cell using optical tweezers

Ling Gu; Argha Mondal; Homa Homayoni; Kytai Nguyen; Samarendra Mohanty

doi:10.1117/12.930588

10 October 2012 Measurement of PLGA-NP interaction with single smooth muscle cells using optical tweezers

Ling Gu, Argha Mondal, Homa Homayoni, Kytai Nguyen, Samarendra Mohanty

Proceedings Volume 8460, Biosensing and Nanomedicine V; 846007 (2012) https://doi.org/10.1117/12.930588
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

For intervention of cardiovascular diseases, biodegradable and biocompatible, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) are emerging as agents of choice for controlled and targeted drug delivery. Therefore development of PLGA-NP with optimal physico-chemical properties will allow efficient binding and thus delivery of drug to targeted cells under various patho-physiological conditions. The force kinetics and its dependence on size of the NPs will be crucial for designing the NPs. Since optical tweezers allow non-contact, highly sensitive force measurement with high spatial and temporal resolution, we utilized it for studying interaction forces between magnetic PLGA nanoparticles with smooth muscle cells (SMC). In order to investigate effect of size, interaction force for 200 to 1100nm PLGA NP was measured. For similar interaction duration, the force was found to be higher with increase in size. The rupture force was found to depend on time of interaction of SMC with NPs.

Citation Download Citation

Ling Gu, Argha Mondal, Homa Homayoni, Kytai Nguyen, and Samarendra Mohanty "Measurement of PLGA-NP interaction with single smooth muscle cells using optical tweezers", Proc. SPIE 8460, Biosensing and Nanomedicine V, 846007 (10 October 2012); https://doi.org/10.1117/12.930588

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