Automated malignancy detection in breast histopathological images

Andrei Chekkoury; Parmeshwar Khurd; Jie Ni; Claus Bahlmann; Ali Kamen; Amar Patel; Leo Grady; Maneesh Singh; Martin Groher; Nassir Navab; Elizabeth Krupinski; Jeffrey Johnson; Anna Graham; Ronald Weinstein

doi:10.1117/12.911643

23 February 2012 Automated malignancy detection in breast histopathological images

Andrei Chekkoury, Parmeshwar Khurd, Jie Ni, Claus Bahlmann, Ali Kamen, Amar Patel, Leo Grady, Maneesh Singh, Martin Groher, Nassir Navab, Elizabeth Krupinski, Jeffrey Johnson, Anna Graham, Ronald Weinstein

Author Affiliations +

Proceedings Volume 8315, Medical Imaging 2012: Computer-Aided Diagnosis; 831515 (2012) https://doi.org/10.1117/12.911643
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

Detection of malignancy from histopathological images of breast cancer is a labor-intensive and error-prone process. To streamline this process, we present an efficient Computer Aided Diagnostic system that can differentiate between cancerous and non-cancerous H&E (hemotoxylin&eosin) biopsy samples. Our system uses novel textural, topological and morphometric features taking advantage of the special patterns of the nuclei cells in breast cancer histopathological images. We use a Support Vector Machine classifier on these features to diagnose malignancy. In conjunction with the maximum relevance - minimum redundancy feature selection technique, we obtain high sensitivity and specificity. We have also investigated the effect of image compression on classification performance.

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Andrei Chekkoury, Parmeshwar Khurd, Jie Ni, Claus Bahlmann, Ali Kamen, Amar Patel, Leo Grady, Maneesh Singh, Martin Groher, Nassir Navab, Elizabeth Krupinski, Jeffrey Johnson, Anna Graham, and Ronald Weinstein "Automated malignancy detection in breast histopathological images", Proc. SPIE 8315, Medical Imaging 2012: Computer-Aided Diagnosis, 831515 (23 February 2012); https://doi.org/10.1117/12.911643

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