Experimental comparison of perfusion imaging systems using multi-exposure laser speckle, single-exposure laser speckle, and full-field laser Doppler

Oliver Thompson; Jimmy Bakker; Carla Kloeze; Erwin Hondebrink; Wiendelt Steenbergen

doi:10.1117/12.907618

9 February 2012 Experimental comparison of perfusion imaging systems using multi-exposure laser speckle, single-exposure laser speckle, and full-field laser Doppler

Oliver Thompson, Jimmy Bakker, Carla Kloeze, Erwin Hondebrink, Wiendelt Steenbergen

Author Affiliations +

Proceedings Volume 8222, Dynamics and Fluctuations in Biomedical Photonics IX; 822204 (2012) https://doi.org/10.1117/12.907618
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

A variety of laser Doppler and laser speckle contrast systems have been constructed by various groups and companies, for commercial sale and for research. All rely on the same physical phenomenon - the dynamic laser speckle pattern generated by illuminating tissue with coherent light - but differ in details of system design, operation and analysis. We present a comparison between measurements made with three systems: a multi-exposure laser speckle contrast system built at Industrial Research Ltd, a commercial single-exposure laser speckle contrast system developed by Perimed AB (PSI NR) and the full-field laser Doppler camera built by the University of Twente (TOPCam). We compare the response to changing flows of all three systems. The systems are found to produce similar results for a variety of in-vivo and in-vitro measurements. Multi-exposure speckle contrast shows some advantages in information gained and insensitivity to static speckle, at the cost of increased complexity and measurement time.

Citation Download Citation

Oliver Thompson, Jimmy Bakker, Carla Kloeze, Erwin Hondebrink, and Wiendelt Steenbergen "Experimental comparison of perfusion imaging systems using multi-exposure laser speckle, single-exposure laser speckle, and full-field laser Doppler", Proc. SPIE 8222, Dynamics and Fluctuations in Biomedical Photonics IX, 822204 (9 February 2012); https://doi.org/10.1117/12.907618

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