Profiling wound healing with wound effluent: Raman spectroscopic indicators of infection

Nicole J. Crane; Eric A. Elster

doi:10.1117/12.909405

31 January 2012 Profiling wound healing with wound effluent: Raman spectroscopic indicators of infection

Nicole J. Crane, Eric A. Elster

Proceedings Volume 8220, Optical Biopsy X; 82200S (2012) https://doi.org/10.1117/12.909405
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The care of modern traumatic war wounds remains a significant challenge for clinicians. Many of the extremity wounds inflicted during Operation Enduring Freedom and Operation Iraqi Freedom are colonized or infected with multi-drug resistant organisms, particularly Acinetobacter baumannii. Biofilm formation and resistance to current treatments can significantly confound the wound healing process. Accurate strain identification and targeted drug administration for the treatment of wound bioburden has become a priority for combat casualty care. In this study, we use vibrational spectroscopy to examine wound exudates for bacterial load. Inherent chemical differences in different bacterial species and strains make possible the high specificity of vibrational spectroscopy.

Citation Download Citation

Nicole J. Crane and Eric A. Elster "Profiling wound healing with wound effluent: Raman spectroscopic indicators of infection", Proc. SPIE 8220, Optical Biopsy X, 82200S (31 January 2012); https://doi.org/10.1117/12.909405

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