Compact Stokes shift and fluorescence spectroscopic diagnostics LED ratiometer unit with no moving parts for cancer detection

Laura A. Sordillo; Yang Pu; Yury Budansky; R. R. Alfano

doi:10.1117/12.906487

16 February 2012 Compact Stokes shift and fluorescence spectroscopic diagnostics LED ratiometer unit with no moving parts for cancer detection

Laura A. Sordillo, Yang Pu, Yury Budansky, R. R. Alfano

Author Affiliations +

Proceedings Volume 8220, Optical Biopsy X; 82200I (2012) https://doi.org/10.1117/12.906487
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

A compact Stokes shift and fluorescence spectroscopy (S3) LED device with no moving parts is presented. This device can be used diagnostically for the identification of the native biomolecules within cancerous tissue samples. This S3-LED ratiometer unit measures both the emission and absorption spectra of key native organic biomolecules within a tissue sample by using multiple wavelength LEDs (light emitting diodes) coupled to an optical fiber. Thus, an optical fingerprint of the sample can be obtained. This technique could be used to distinguish benign and malignant tissues, and to check for residual or recurrent carcinoma after treatment, thus reducing the necessity of second biopsies. The S3-LED ratiometer unit was tested in vitro on human breast malignant and normal paired tissue samples.

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Laura A. Sordillo, Yang Pu, Yury Budansky, and R. R. Alfano "Compact Stokes shift and fluorescence spectroscopic diagnostics LED ratiometer unit with no moving parts for cancer detection", Proc. SPIE 8220, Optical Biopsy X, 82200I (16 February 2012); https://doi.org/10.1117/12.906487

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