Analysis of soft tissue near infrared spectra under dynamic pressure effects

Blaž Cugmas; Miran Bürmen; Franjo Pernuš; Boštjan Likar

doi:10.1117/12.908614

31 January 2012 Analysis of soft tissue near infrared spectra under dynamic pressure effects

Blaž Cugmas, Miran Bürmen, Franjo Pernuš, Boštjan Likar

Proceedings Volume 8220, Optical Biopsy X; 822007 (2012) https://doi.org/10.1117/12.908614
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Near infrared (NIR) diffuse reflectance spectroscopy is a rapid noninvasive spectroscopic technique extensively used in the field of biomedicine. The main challenges of the NIR spectroscopy lie in the analysis of the acquired spectral information, requiring prior knowledge on the influence of various tissue parameters on the spectra. In this paper, we focus on the influence of pressure on the soft tissues NIR spectra. The existing studies based on static measurements showed that pressure tends to decrease the diffuse reflectance of the soft tissue. The purpose of this study was to further analyze the effects of static and in particular dynamically changing pressure on the soft tissue diffuse reflectance properties and assess its potential for tissue classification. For this purpose, a custom real-time system for rapid acquisition of NIR diffuse reflectance spectra of tissue under controlled static or dynamically changing pressure was developed. The study was conducted using porcine ribs and porcine liver (in vitro) tissue samples and human skin (in vivo). The acquired spectra were preprocessed by mean centering or standard normal variate and analyzed by Principal Component Analysis (PCA). A polynomial function was used to model the first three calculated scores as a function of the applied pressure. It was found, that the median values of the calculated polynomial coefficients were significantly different for all the samples, indicating reflectance changes due to the applied pressure could be used for classification of biological tissues.

Citation Download Citation

Blaž Cugmas, Miran Bürmen, Franjo Pernuš, and Boštjan Likar "Analysis of soft tissue near infrared spectra under dynamic pressure effects", Proc. SPIE 8220, Optical Biopsy X, 822007 (31 January 2012); https://doi.org/10.1117/12.908614

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