Image-guided intervention in the human bile duct using scanning fiber endoscope system

Eric J. Seibel; Javier A. Jo; C. David Melville; Richard S. Johnston; Christopher R. Naumann; Michael D. Saunders

doi:10.1117/12.910070

30 January 2012 Image-guided intervention in the human bile duct using scanning fiber endoscope system

Eric J. Seibel, Javier A. Jo, C. David Melville, Richard S. Johnston, Christopher R. Naumann, Michael D. Saunders

Proceedings Volume 8218, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XII; 82180B (2012) https://doi.org/10.1117/12.910070
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Bile duct cancers are increasing in frequency while being difficult to diagnose. Currently available endoscopic imaging devices used in the biliary tree are low resolution with poor image quality, leading to inadequate evaluation of indeterminate biliary strictures. However, a new ultrathin and flexible cholangioscope system has been successfully demonstrated in a human subject. This mini-cholangioscope system uses a scanning fiber endoscope (SFE) as a forward-imaging guidewire, dimensions of 1.2-mm diameter and 3-m length. Full color video (500-line resolution at 30Hz) is the standard SFE imaging mode using spiral scanning of red, green, and blue laser light at low power. Image-guided operation of the biopsy forceps was demonstrated in healthy human bile ducts with and without saline flushing. The laser-based video imaging can be switched to various modes to enhance tissue markers of disease, such as widefield fluorescence and enhanced spectral imaging. In parallel work, biochemical discrimination of tissue health in pig bile duct has been accomplished using fiberoptic delivery of pulsed UV illumination and time-resolved autofluorescence spectroscopic measurements. Implementation of time-resolved fluorescence spectroscopy for biochemical assessment of the bile duct wall is being done through a secondary endoscopic channel. Preliminary results indicate that adequate SNR levels (> 30 dB) can be achieved through a 50 micron fiber, which could serve as an optical biopsy probe. The SFE is an ideal mini-cholangioscope for integration of both tissue and molecular specific image contrast in the future. This will provide the physician with unprecedented abilities to target biopsy locations and perform endoscopically-guided therapies.

Citation Download Citation

Eric J. Seibel, Javier A. Jo, C. David Melville, Richard S. Johnston, Christopher R. Naumann, and Michael D. Saunders "Image-guided intervention in the human bile duct using scanning fiber endoscope system", Proc. SPIE 8218, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XII, 82180B (30 January 2012); https://doi.org/10.1117/12.910070

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