Development of a widefield SERS imaging endoscope

Patrick Z. McVeigh; Rupananda J. Mallia; Israel Veilleux; Brian C. Wilson

doi:10.1117/12.907304

1 March 2012 Development of a widefield SERS imaging endoscope

Patrick Z. McVeigh, Rupananda J. Mallia, Israel Veilleux, Brian C. Wilson

Proceedings Volume 8217, Endoscopic Microscopy VII; 821704 (2012) https://doi.org/10.1117/12.907304
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We report on the design and testing of a prototype widefield surface enhanced Raman scattering (SERS) imaging system based on a fiber optic bronchoscope using bandpass filters for Raman signal selection. The SERS contrast agents employed consist of gold nanoparticles encoded with a Raman-active dye and made specific for lung adenocarcinoma tissue through the use of an anti-epidermal growth factor receptor (EGFR) antibody. By exploiting the extremely narrow SERS spectral peaks we demonstrate a facile method of background fluorescence rejection that can be implemented at sub-video rates. The system has been tested on in-vivo tissues and performance metrics, including the maximum tissue penetration and minimum detectable nanoparticle quantity have been determined in a standardized fashion.

Citation Download Citation

Patrick Z. McVeigh, Rupananda J. Mallia, Israel Veilleux, and Brian C. Wilson "Development of a widefield SERS imaging endoscope", Proc. SPIE 8217, Endoscopic Microscopy VII, 821704 (1 March 2012); https://doi.org/10.1117/12.907304

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