Lung vasculature imaging using speckle variance optical coherence tomography

Michelle Cua; Anthony M. D. Lee; Pierre M. Lane; Annette McWilliams; Tawimas Shaipanich; Calum E. MacAulay; Victor X. D. Yang; Stephen Lam

doi:10.1117/12.906903

17 February 2012 Lung vasculature imaging using speckle variance optical coherence tomography

Michelle Cua, Anthony M. D. Lee, Pierre M. Lane, Annette McWilliams, Tawimas Shaipanich, Calum E. MacAulay, Victor X. D. Yang, Stephen Lam

Author Affiliations +

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82073P (2012) https://doi.org/10.1117/12.906903
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Architectural changes in and remodeling of the bronchial and pulmonary vasculature are important pathways in diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. However, there is a lack of methods that can find and examine small bronchial vasculature in vivo. Structural lung airway imaging using optical coherence tomography (OCT) has previously been shown to be of great utility in examining bronchial lesions during lung cancer screening under the guidance of autofluorescence bronchoscopy. Using a fiber optic endoscopic OCT probe, we acquire OCT images from in vivo human subjects. The side-looking, circumferentially-scanning probe is inserted down the instrument channel of a standard bronchoscope and manually guided to the imaging location. Multiple images are collected with the probe spinning proximally at 100Hz. Due to friction, the distal end of the probe does not spin perfectly synchronous with the proximal end, resulting in non-uniform rotational distortion (NURD) of the images. First, we apply a correction algorithm to remove NURD. We then use a speckle variance algorithm to identify vasculature. The initial data show a vascaulture density in small human airways similar to what would be expected.

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Michelle Cua, Anthony M. D. Lee, Pierre M. Lane, Annette McWilliams, Tawimas Shaipanich, Calum E. MacAulay, Victor X. D. Yang, and Stephen Lam "Lung vasculature imaging using speckle variance optical coherence tomography", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82073P (17 February 2012); https://doi.org/10.1117/12.906903

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