In vivo longitudinal photoacoustic imaging of subcutaneous tumours in mice

Jan Laufer; Peter Johnson; Edward Zhang; Bradley Treeby; Ben Cox; Barbara Pedley; Paul Beard

doi:10.1117/12.876782

28 February 2011 In vivo longitudinal photoacoustic imaging of subcutaneous tumours in mice

Jan Laufer, Peter Johnson, Edward Zhang, Bradley Treeby, Ben Cox, Barbara Pedley, Paul Beard

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 789915 (2011) https://doi.org/10.1117/12.876782
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Photoacoustic tomography can provide high resolution 3D images of vascular networks, making it well suited to characterising the development of tumour vasculature and its response to treatment. In this study, photoacoustic images to depths of up to 9 mm were obtained using an all optical ultrasound detection scheme. Two type of colorectal tumours (LS174T and SW1222) implanted subcutaneously in a mouse were studied. 3D photoacoustic images were obtained in vivo revealing the different vascular architectures of each tumour type and their evolution over a period of several days. The results suggest that photoacoustic imaging could play a role in providing essential pre-clinical information on tumour pathophysiology and eliciting the biological mechanisms underlying anti-angiogenic therapies and other treatments.

Citation Download Citation

Jan Laufer, Peter Johnson, Edward Zhang, Bradley Treeby, Ben Cox, Barbara Pedley, and Paul Beard "In vivo longitudinal photoacoustic imaging of subcutaneous tumours in mice", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789915 (28 February 2011); https://doi.org/10.1117/12.876782

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available