Spatially-resolved probing of biological phantoms by point-radiance spectroscopy

Serge Grabtchak; Tyler J. Palmer; William M. Whelan

doi:10.1117/12.874042

16 February 2011 Spatially-resolved probing of biological phantoms by point-radiance spectroscopy

Serge Grabtchak, Tyler J. Palmer, William M. Whelan

Author Affiliations +

Proceedings Volume 7894, Optical Fibers, Sensors, and Devices for Biomedical Diagnostics and Treatment XI; 78940A (2011) https://doi.org/10.1117/12.874042
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Interstitial fiber-optic based strategies for therapy monitoring and assessment rely on detecting treatment-induced changes in the light distribution in biological tissues. We present an optical technique to identify spectrally and spatially specific tissue chromophores in highly scattering turbid media. Typical optical sensors measure non-directional light intensity (i.e. fluence) and require fiber translation (i.e. 3-5 positions), which is difficult to implement clinically. Point radiance spectroscopy is based on directional light collection (i.e. radiance) at a single point with a side-firing fiber that can be rotated up to 360°. A side firing fiber accepts light within a well-defined solid angle thus potentially providing an improved spatial resolution. Experimental measurements were performed using an 800-μm diameter isotropic spherical diffuser coupled to a halogen light source and a 600 μm, ~43° cleaved fiber (i.e. radiance detector). The background liquid-based scattering phantom was fabricated using 1% Intralipid (i.e. scattering medium). Light was collected at 1-5° increments through 360°-segment. Gold nanoparticles, placed into a 3.5 mm diameter capillary tube were used as localized scatterers and absorbers introduced into the liquid phantom both on- and off-axis between source and detector. The localized optical inhomogeneity was detectable as an angular-resolved variation in the radiance polar plots. This technique is being investigated as a non-invasive optical modality for prostate cancer monitoring.

Citation Download Citation

Serge Grabtchak, Tyler J. Palmer, and William M. Whelan "Spatially-resolved probing of biological phantoms by point-radiance spectroscopy", Proc. SPIE 7894, Optical Fibers, Sensors, and Devices for Biomedical Diagnostics and Treatment XI, 78940A (16 February 2011); https://doi.org/10.1117/12.874042

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