Evaluation of the effect of laser radiation on fibroblast proliferation in repair of skin wounds of rats with iron deficiency anemia

Isabele C. V. DeCastro; Susana C. P. Oliveira-Sampaio; Juliana S. de C. Monteiro; Maria de Fátima L. Ferreira; Maria T. Cangussu; Jean N. dos Santos; Antonio Luiz B. Pinheiro

doi:10.1117/12.874222

17 February 2011 Evaluation of the effect of laser radiation on fibroblast proliferation in repair of skin wounds of rats with iron deficiency anemia

Isabele C. V. DeCastro, Susana C. P. Oliveira-Sampaio, Juliana S. de C. Monteiro, Maria de Fátima L. Ferreira, Maria T. Cangussu, Jean N. dos Santos, Antonio Luiz B. Pinheiro

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Proceedings Volume 7887, Mechanisms for Low-Light Therapy VI; 78870R (2011) https://doi.org/10.1117/12.874222
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The aim of this study was to assess the effect of low- level laser therapy (LLLT) on fibroblast proliferation on wound repair of rats with Iron deficiency anemia since there is no reports on literature about this subject. Iron deficiency anemia was induced on 36 newborn rats then an excisional wound was created on the dorsum of the animals which were divided into four groups: (I) - non-anemic, (II) - Anemic, (III) - non-anemic + LLLT, (IV) Anemic+ LLLT. The animals in each group were sacrificed at 7, 14 and 21 days. Laser irradiation was performed on each group (λ660nm,40Mw,CW) by contact mode with a dose of 2,5J/ cm² in four points on the area of the wound and total of 10J/cm² per session. Data were evaluated by analysis of variance (ANOVA) followed by Paired t-test. The results showed LLLT was able to stimulate fibroblastic proliferation in rats with iron deficiency anemia at the 21st day while at control group (III) no statistically significant differences was found.

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Isabele C. V. DeCastro, Susana C. P. Oliveira-Sampaio, Juliana S. de C. Monteiro, Maria de Fátima L. Ferreira, Maria T. Cangussu, Jean N. dos Santos, and Antonio Luiz B. Pinheiro "Evaluation of the effect of laser radiation on fibroblast proliferation in repair of skin wounds of rats with iron deficiency anemia", Proc. SPIE 7887, Mechanisms for Low-Light Therapy VI, 78870R (17 February 2011); https://doi.org/10.1117/12.874222

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