In utero mouse embryonic imaging with OCT for ophthalmologic research

Saba H. Syed; Irina V. Larina; Mary E. Dickinson; Kirill V. Larin

doi:10.1117/12.875075

11 February 2011 In utero mouse embryonic imaging with OCT for ophthalmologic research

Saba H. Syed, Irina V. Larina, Mary E. Dickinson, Kirill V. Larin

Proceedings Volume 7885, Ophthalmic Technologies XXI; 788508 (2011) https://doi.org/10.1117/12.875075
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Live imaging of an eye during embryonic development in mammalian model is important for understanding dynamic aspects of normal and abnormal eye morphogenesis. In this study, we used Swept Source Optical Coherence Tomography (SS-OCT) for live structural imaging of mouse embryonic eye through the uterine wall. The eye structure was reconstructed in mouse embryos at 13.5 to 17.5 days post coitus (dpc). Despite the limited imaging depth of OCT in turbid tissues, we were able to visualize the whole eye globe at these stages. These results suggest that live in utero OCT imaging is a useful tool to study embryonic eye development in the mouse model.

Citation Download Citation

Saba H. Syed, Irina V. Larina, Mary E. Dickinson, and Kirill V. Larin "In utero mouse embryonic imaging with OCT for ophthalmologic research", Proc. SPIE 7885, Ophthalmic Technologies XXI, 788508 (11 February 2011); https://doi.org/10.1117/12.875075

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