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The multiple resistances to treatment, developed by bacteria and malignant tumors require finding
alternatives to the existing medicines and treatment procedures. One of them is strengthening the effects of
cytostatics by improving the delivery method. Such a method is represented by the use of medicines as
micro/nano-droplets. This method can reduce the substance consumption by generating drug micro-droplets
incorporated in substances that can favour a faster localization, than the classical mode of medicine
administration, to the tumor tissues.
This paper contains the results concerning the generation and study of micro/nano-droplets and the
generation of micro-droplets with an inner core (medicine) and a thin layer covering it. We have measured the
surface tension at water/air interface and water/oil interface for a medicine (Vancomycin) and we have
generated and measured droplets of medicine containing a layer of Vitamin A by using a double capillary
system.
The micro/nano-droplets may be produced by mixing of two immiscible solutions in particular conditions (high
rotating speed and/or high pressure difference). For this we have studied the generation of emulsions of
vitamin A diluted in sunflower oil and a solution of a surfactant Tween 80 in distilled water. The concentration
of surfactant in water was typically 4*10-5M. We have studied in a batch stirred tank system the dependence
of the droplet dimensions in emulsion, function of the mixing rotation speed, agitation time and components
ratio.
The droplet diameters were measured using a Malvern light scattering instrument type Mastersizer Hydro
2000M. We have obtained droplets with diameters smaller than 100 nm; the diameters distribution exhibited a
peak at 65 nm.
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