Local plasmonic resonance based biosensor for investigating DNA hybridization using ellipsometry

Rakesh Singh Moirangthem; Yia-Chung Chang; Pei-Kuen Wei

doi:10.1117/12.862921

10 September 2010 Local plasmonic resonance based biosensor for investigating DNA hybridization using ellipsometry

Rakesh Singh Moirangthem, Yia-Chung Chang, Pei-Kuen Wei

Proceedings Volume 7757, Plasmonics: Metallic Nanostructures and Their Optical Properties VIII; 77573J (2010) https://doi.org/10.1117/12.862921
Event: SPIE NanoScience + Engineering, 2010, San Diego, California, United States

Abstract

A label free, non-destructive and high sensitivity biosensor with sub-nanometer thickness resolution is presented. We investigate various sequences of DNA attached on gold nanoparticles (AuNPs) on top of a layer of self assembling molecules. A strategy to amplify localized surface plasmon resonance (LSPR) response is made by sandwiching DNA sequences between two AuNPs. We monitor the induced changes in polarization state or phase of reflected light from the surface as a function of the photon energy as a sensor signal by using ellipsometry and compare that with theoretical simulation.

Citation Download Citation

Rakesh Singh Moirangthem, Yia-Chung Chang, and Pei-Kuen Wei "Local plasmonic resonance based biosensor for investigating DNA hybridization using ellipsometry", Proc. SPIE 7757, Plasmonics: Metallic Nanostructures and Their Optical Properties VIII, 77573J (10 September 2010); https://doi.org/10.1117/12.862921

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