Hydrogel-based piezoresistive biochemical microsensors

Margarita Guenther; Volker Schulz; Gerald Gerlach; Thomas Wallmersperger; Florian Solzbacher; Jules J. Magda; Prashant Tathireddy; Genyao Lin; Michael P. Orthner

doi:10.1117/12.847373

9 April 2010 Hydrogel-based piezoresistive biochemical microsensors

Margarita Guenther, Volker Schulz, Gerald Gerlach, Thomas Wallmersperger, Florian Solzbacher, Jules J. Magda, Prashant Tathireddy, Genyao Lin, Michael P. Orthner

Author Affiliations +

Proceedings Volume 7642, Electroactive Polymer Actuators and Devices (EAPAD) 2010; 764227 (2010) https://doi.org/10.1117/12.847373
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2010, San Diego, California, United States

Abstract

This work is motivated by a demand for inexpensive, robust and reliable biochemical sensors with high signal reproducibility and long-term-stable sensitivity, especially for medical applications. Micro-fabricated sensors can provide continuous monitoring and on-line control of analyte concentrations in ambient aqueous solutions. The piezoresistive biochemical sensor containing a special biocompatible polymer (hydrogel) with a sharp volume phase transition in the neutral physiological pH range near 7.4 can detect a specific analyte, for example glucose. Thereby the hydrogel-based biochemical sensors are useful for the diagnosis and monitoring of diabetes. The response of the glucosesensitive hydrogel was studied at different regimes of the glucose concentration change and of the solution supply. Sensor response time and accuracy with which a sensor can track gradual changes in glucose was estimated. Additionally, the influence of various recommended sterilization methods on the gel swelling properties and on the mechano-electrical transducer of the pH-sensors has been evaluated in order to choose the most optimal sterilization method for the implantable sensors. It has been shown that there is no negative effect of gamma irradiation with a dose of 25.7 kGy on the hydrogel sensitivity. In order to achieve an optimum between sensor signal amplitude and sensor response time, corresponding calibration and measurement procedures have been proposed and evaluated for the chemical sensors.

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Margarita Guenther, Volker Schulz, Gerald Gerlach, Thomas Wallmersperger, Florian Solzbacher, Jules J. Magda, Prashant Tathireddy, Genyao Lin, and Michael P. Orthner "Hydrogel-based piezoresistive biochemical microsensors", Proc. SPIE 7642, Electroactive Polymer Actuators and Devices (EAPAD) 2010, 764227 (9 April 2010); https://doi.org/10.1117/12.847373

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