Three-dimensional ultrasound-based texture analysis of the effect of atorvastatin on carotid atherosclerosis

Joseph Awad; Adam Krasinski; David Spence; Grace Parraga; Aaron Fenster

doi:10.1117/12.844371

9 March 2010 Three-dimensional ultrasound-based texture analysis of the effect of atorvastatin on carotid atherosclerosis

Joseph Awad, Adam Krasinski, David Spence, Grace Parraga, Aaron Fenster

Author Affiliations +

Proceedings Volume 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging; 762621 (2010) https://doi.org/10.1117/12.844371
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Carotid atherosclerosis is the major cause of ischemic stroke, a leading cause of death and disability. This is driving the development of image analysis methods to quantitatively evaluate local arterial effects of potential treatments of carotid disease. Here we investigate the use of novel texture analysis tools to detect potential changes in the carotid arteries after statin therapy. Three-dimensional (3D) carotid ultrasound images were acquired from the left and right carotid arteries of 35 subjects (16 treated with 80 mg atorvastatin and 19 treated with placebo) at baseline and after 3 months of treatment. Two-hundred and seventy texture features were extracted from 3D ultrasound carotid artery images. These images previously had their vessel walls (VW) manually segmented. Highly ranked individual texture features were selected and compared to the VW volume (VWV) change using 3 measures: distance between classes, Wilcoxon rank sum test, and accuracy of the classifiers. Six classifiers were used. Using texture feature (L7R7) increases the average accuracy and area under the ROC curve to 74.4% and 0.72 respectively compared to 57.2% and 0.61 using VWV change. Thus, the results demonstrate that texture features are more sensitive in detecting drug effects on the carotid vessel wall than VWV change.

Citation Download Citation

Joseph Awad, Adam Krasinski, David Spence, Grace Parraga, and Aaron Fenster "Three-dimensional ultrasound-based texture analysis of the effect of atorvastatin on carotid atherosclerosis", Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 762621 (9 March 2010); https://doi.org/10.1117/12.844371

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Arteries

3D image processing

Distance measurement

3D acquisition

Image segmentation

Ultrasonography

Feature extraction

Show All Keywords

Keywords/Phrases

Search In:

Publication Years