Synthesis of a dual contrast agent for ultrasound and photoacoustic imaging

Katheryne Wilson; Kimberly Homan; Stanislav Emelianov

doi:10.1117/12.841431

16 February 2010 Synthesis of a dual contrast agent for ultrasound and photoacoustic imaging

Katheryne Wilson, Kimberly Homan, Stanislav Emelianov

Proceedings Volume 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II; 75760M (2010) https://doi.org/10.1117/12.841431
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

A dual contrast agent that combines perfluorocarbon droplets and metal nanoparticles has been developed for combined ultrasound and photoacoustic imaging. Metal nanoparticles were incorporated in dodecafluoropentane (DDFP) droplets encapsulated in a bovine serum albumin (BSA) shell. To embed aqueous colloidal suspensions of metal nanoparticles in DDFP, a phase transfer of the plasmonic nanoparticles was completed in two different strategies, a single and a double ligand exchange of capping materials. Emulsion techniques were used to encapsulate phase transferred metal nanoparticles within the DDFP droplets. Spectrophotometry and cryogenic transmission electron microscopy were used to characterize and to confirm successful fabrication of the dual contrast agent.

Citation Download Citation

Katheryne Wilson, Kimberly Homan, and Stanislav Emelianov "Synthesis of a dual contrast agent for ultrasound and photoacoustic imaging", Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760M (16 February 2010); https://doi.org/10.1117/12.841431

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