Development of a real-time closed-loop dual-wavelength optical polarimeter for glucose monitoring

Bilal H. Malik; Gerard L. Coté

doi:10.1117/12.842642

17 February 2010 Development of a real-time closed-loop dual wavelength optical polarimeter for glucose monitoring

Bilal H. Malik, Gerard L. Coté

Proceedings Volume 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics; 757202 (2010) https://doi.org/10.1117/12.842642
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Over the last decade, noninvasive glucose sensors based on optical polarimetry have been proposed to probe the anterior chamber of the eye. Such sensors would ultimately be used to measure the aqueous humor glucose concentration which is correlated with blood glucose concentration. Although the effect of other chiral components in the eye has been minimized, the time-variant corneal birefringence due to motion artifact is still a limiting factor which needs to be resolved for realization of such a device. Here we present the development of a real-time dual wavelength optical polarimetric system employing a classical three-term feedback controller. Our dual wavelength system utilizes real-time closed-loop feedback based on proportional-integral-derivative (PID) control, which effectively reduced the time taken by the system to stabilize to less than 300 ms while minimizing the effect of motion artifact, which appears as common noise source for both wavelengths. Measurements in the presence of time-variant test cell birefringence demonstrate the sensitivity of the current system to measure glucose within the range of 0-600 mg/dl with a standard error of less than 13 mg/dl using the dual wavelength information.

Citation Download Citation

Bilal H. Malik and Gerard L. Coté "Development of a real-time closed-loop dual wavelength optical polarimeter for glucose monitoring", Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 757202 (17 February 2010); https://doi.org/10.1117/12.842642

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Glucose

Polarimetry

Birefringence

Control systems

Error analysis

Blood

Eye

Show All Keywords

Keywords/Phrases

Search In:

Publication Years