Regularization in fluorescence diffuse optical tomography using prior information on the medium optical properties

E. Péry; L. Hervé; J. M. Dinten; F. Peyrin

doi:10.1117/12.841368

23 February 2010 Regularization in fluorescence diffuse optical tomography using prior information on the medium optical properties

E. Péry, L. Hervé, J. M. Dinten, F. Peyrin

Author Affiliations +

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570V (2010) https://doi.org/10.1117/12.841368
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

It is well known that the reconstruction problem in fluorescence diffuse optical tomography is badly conditioned and requires the knowledge of medium optical properties. Its principle is to measure the fluorescence light emerging at different positions of the surface when the biological medium is excited with point sources. In this paper, we evaluate the influence of the medium optical properties and the noise on the fluorescence reconstruction, and we introduce a new regularized fluorescence reconstruction method using an a priori on contours. The fluorescence reconstruction improvement is studied when using this method.

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E. Péry, L. Hervé, J. M. Dinten, and F. Peyrin "Regularization in fluorescence diffuse optical tomography using prior information on the medium optical properties", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570V (23 February 2010); https://doi.org/10.1117/12.841368

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