Rapid optical heating of blood for clinical point-of-care diagnostics

Brian E. Catanzaro; Ted Hill; Steve Hankins; Kent Gandola

doi:10.1117/12.842881

19 February 2010 Rapid optical heating of blood for clinical point-of-care diagnostics

Brian E. Catanzaro, Ted Hill, Steve Hankins, Kent Gandola

Proceedings Volume 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII; 75550S (2010) https://doi.org/10.1117/12.842881
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Clinical testing of human blood requires adherence to a number of regulatory standards, including maintaining a temperature that is representative of the human body (e.g. 37 C). The economics of private and public healthcare drives blood assays to be conducted using low cost, disposable assay devices that also eliminate the possibility of cross contamination. Unfortunately, the materials that meet the economic and disposable constraints of the marketplace are thermal insulators, not ideal for rapid heating. We present a novel means of optically heating blood samples in plastic assay devices within a time period suitable for point-of-care use. The novel approach uses LED's in the red portion of the visible spectrum. The lower absorption of optical radiation in the visible spectrum enables the absorption of energy deep into the assay device. This produces even heating, avoiding the gradients that can occur by surface heating (conduction) or surface absorption (highly absorbing wavelengths). Analytical and computational models will be discussed. A specific application to a point-of-care blood assay instrument will be reviewed. In this application, optical heating was achieved using a small array of high brightness LED's. Experimental results will be discussed. The experimental results with this instrument validated the predictions.

Citation Download Citation

Brian E. Catanzaro, Ted Hill, Steve Hankins, and Kent Gandola "Rapid optical heating of blood for clinical point-of-care diagnostics", Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75550S (19 February 2010); https://doi.org/10.1117/12.842881

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available