Enhancing protoporphyrin IX-induced PDT

Alison Curnow; Andrew Pye; Sandra Campbell

doi:10.1117/12.822241

13 July 2009 Enhancing protoporphyrin IX-induced PDT

Alison Curnow, Andrew Pye, Sandra Campbell

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738010 (2009) https://doi.org/10.1117/12.822241
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Photodynamic therapy (PDT) using porphyrin precursors is commonly used in dermatology. Evidence indicates that good clinical outcomes (associated with excellent cosmesis) can be achieved in superficial precancers and basal cell carcinoma (BCC), however, efficacy appears less favorable for thicker nodular BCC (nBCC) unless multiple PDT treatment cycles are performed. Enhancement is therefore required if nBCC lesions are to be treated effectively with a single PDT treatment. The most common technique currently being routinely employed clinically is the use of aminolevulinic acid (ALA) esters (usually methyl (MAL) or hexyl (HAL)). Standard dermatological PDT employing these porphyrin precursors already manipulates the normal heme biosynthesis pathway resulting in a temporary accumulation of the natural photosensitizer, protoporphyrin IX (PpIX). Further manipulation using iron chelating agents is possible however. In normal and malignant human cells in vitro, the novel iron chelating agent CP94 produced greater PPIX fluorescence when administered with ALA or MAL than either congener produced alone. CP94 was also significantly more effective than the clinically established iron chelating agent desferrioxamine (DFO). Topical application of ALA+CP94 to clinical nBCC lesions was a simple and safe treatment modification which produced a significant increase in clinical clearance when CP94 was included in the cream.

Citation Download Citation

Alison Curnow, Andrew Pye, and Sandra Campbell "Enhancing protoporphyrin IX-induced PDT", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738010 (13 July 2009); https://doi.org/10.1117/12.822241

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