Nano-&#946;-tricalcium phosphate/collagen materials with improved biostability for bone replacement applications

Oana Craciunescu; Christu Tardei; Lucia Moldovan

doi:10.1117/12.823658

7 January 2009 Nano-β-tricalcium phosphate/collagen materials with improved biostability for bone replacement applications

Oana Craciunescu, Christu Tardei, Lucia Moldovan

Author Affiliations +

Proceedings Volume 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV; 72971B (2009) https://doi.org/10.1117/12.823658
Event: Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 2008, Constanta, Romania

Abstract

Three mixtures of collagen (COL) solution and nano-β-tricalcium phosphate (n-β-TCP) powder, with dry weight ratios of 1:1; 1:2.6 and 1:5, respectively were prepared. After freeze-drying, porous three-dimensional (3D) scaffolds were obtained. COL/β-n-TCP scaffolds were chemically crosslinked by treatment with carbodiimide. The crosslinking degree, assessed by quantification of free amine groups, decreased with increasing n-β-TCP quantities. In vitro degradation test showed a better biostability of the chemically cross-linked scaffolds over non-treated ones. All crosslinked scaffolds presented a good cytocompatibility and supported cell proliferation at 48 h and 72 h after cell seeding. These results indicated that EDC cross-linked COL/n-β-TCP scaffolds are potential candidates for bone substitutes with enhanced biostability and good biocompatibility.

Citation Download Citation

Oana Craciunescu, Christu Tardei, and Lucia Moldovan "Nano-β-tricalcium phosphate/collagen materials with improved biostability for bone replacement applications", Proc. SPIE 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 72971B (7 January 2009); https://doi.org/10.1117/12.823658

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KEYWORDS

Bone

Composites

In vitro testing

Collagen

Calcium

Ceramics

Crystals

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