Anna G. Orlova,1 Vladislav A. Kamensky,1 German Yu. Golubiatnikov,1 Anna V. Maslennikova M.D.,1,2 Vladimir I. Plehanov,1 Natalia M. Shakhova M.D.,1 Mikhail S. Kleshnin,1 Ilya V. Turchin1
1Institute of Applied Physics (Russian Federation) 2Nizhny Novgorod State Medical Academy (Russian Federation)
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Diffuse Optical Tomography (DOT) is based on acquiring information from multiply scattered light which penetrates
into the tissue up to depths of several centimeters. This technique allows for imaging of absorbing and scattering
inclusions inside tissue and distinguishing between them after computer processing of an image. An experimental setup
for multicolor frequency-domain diffuse optical tomography (FD DOT) to visualize neoplasia of breast tissue and to
estimate its size has been created. A breast is scanned in the transilluminative configuration by a single source and
detector pair. Illumination at three wavelengths (684 nm, 794 nm, and 850 nm) which correspond to different parts of the
absorption spectrum provides information about concentration of the main absorbers (oxygenated hemoglobin,
deoxygenated hemoglobin, and fat/water). Source amplitude modulation at 140 MHz increases spatial resolution and
provides separate reconstruction of scattering and absorption coefficients. In vivo study of breast carcinoma has been
performed. Maps of 2D distributions of reconstructed absorption and scattering coefficients and concentration of
hemoglobin have been obtained. An increase of absorption and scattering coefficient, total hemoglobin concentration and
decrease of blood oxygen saturation is observed in the tumor area in comparison with the surrounding tissue. We can
conclude that FD DOT technique confirms a possibility of detecting neoplastic changes.
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Anna G. Orlova, Vladislav A. Kamensky, German Yu. Golubiatnikov, Anna V. Maslennikova M.D., Vladimir I. Plehanov, Natalia M. Shakhova M.D., Mikhail S. Kleshnin, Ilya V. Turchin, "Multicolor frequency-domain diffuse optical tomography for detection of breast cancer," Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741N (12 February 2009); https://doi.org/10.1117/12.807700